It was aimed at to evaluate the activity of Carica papaya fruit juice on induced diabetic rats (Rattus norvegicus) with a view of proposing a management scheme. Animals were sacrificed after treatment with unripe and ripe papaya juice. The plasma glucose, cholesterol and protein were estimated. Feeding of papaya juice rose significantly (p<0.05) the levels of these parameters more than the controlled value throughout the work. The rise was more with unripe papaya when compared to ripe papaya. However, papaya intake must be rationed since its consumption increases blood glucose concentration.