An experiment was conducted during kharif-2012 on soybean crop to test the bio-efficacy of insecticides and plant products against defoliators and stem borer. The results revealed that Indoxacarb 14.5 SC (0.012%) proved to be the most effective. Lambda-cyhalothrin 5 EC (0.0025%) has more efficient against tobacco caterpillar followed by Indoxacarb 14.5 SC (0.012%) and NSKE (5%). While the effectiveness against semilloper of Indoxacarb 14.5 SC (0.012%) proved to be more followed by cypermethrin 10 EC (0.05%), whereas in case of girdle beetle Trizophos 40 EC (0.05%) proved to be most effective followed by cypermethrin 10 EC (0.01%). However, the plant product, tobacco leaf extract (2%) and Azadirachtin 0.15 EC (0.15%) proved to be least effective. The highest cost: benefit ratio was obtained in Lamda-cyhalothrin 5 EC (1: 23.67) which proved to be the most effective followed by cypermethrin 10 EC (1:18.52) and trizophos 40 EC (1:14.98), whereas lowest C:B ratio was recorded in NSKE (1:7.25). The seed yield 2763 kg/ha was recorded with application of Indoxacarb 14.5 SC which was 726 kg (35.64%) more than the control. Other treatments gave additional yield ranging from 2353 to 2753 kg/ha.