The median neurosecretory cells (MNSC) of pre-copulating female Spilostethus pandurus were observed in two groups, each of 4-6 cells and were arranged symmetrically on either side of median fissure. The neurosecretory material of MNSC were stained purple with PF, blue black with CHP and greenish blue with PAVB. The neuro secretory product of MNSC were present in small aggregates or lumps in the perikaryon and in axon hillock in pre-copulating female Spilostethus pandurus, a heteropteran bug of economic importance.