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Year: 2015, Issue: June

Bendiocarb, A carbamate induces genotoxicity and cytotoxicity in bone marrow of Calotes versicolour.

Author:

Anisha and Tumul Singh

Keyword:

Carbamate, Bendiocarb, Micronucleus, Mitotic index, Calotes.
In the present work two very sensitive biomarkers micronucleus (MN) and mitotic index (MI) has been used to test the genotoxic and cytotoxic potentials of bendiocarb, a carbamate insecticide in the bone marrow of Calotes versicolor. Adult male garden lizards were acclimatized for one week in the laboratory and then injected intraperitoneally a daily dose of 8 mg/kg body weight (� LD ) of bendiocarb. The bone marrow was used for scoring 50 (MN) and (MI). Significant increase of MN frequency in polychromatic erythrocytes (PCE) was observed after 14th and 21th days (P<0.05) and after 28th days of treatment (P<0.005). No significant change in frequencies of MI was observed in animals treated with bendiocarb for 7th and 14th days. However, MI frequencies decreased significantly after 21th days (P<0.05) and 28th days (P

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