Bendiocarb, A carbamate induces genotoxicity and cytotoxicity in bone marrow of Calotes versicolour.

Carbamate, Bendiocarb, Micronucleus, Mitotic index, Calotes.

In the present work two very sensitive biomarkers micronucleus (MN) and mitotic index (MI) has been used to test the genotoxic and cytotoxic potentials of bendiocarb, a carbamate insecticide in the bone marrow of Calotes versicolor. Adult male garden lizards were acclimatized for one week in the laboratory and then injected intraperitoneally a daily dose of 8 mg/kg body weight (� LD ) of bendiocarb. The bone marrow was used for scoring 50 (MN) and (MI). Significant increase of MN frequency in polychromatic erythrocytes (PCE) was observed after 14th and 21th days (P<0.05) and after 28th days of treatment (P<0.005). No significant change in frequencies of MI was observed in animals treated with bendiocarb for 7th and 14th days. However, MI frequencies decreased significantly after 21th days (P<0.05) and 28th days (P<0.005) in the treated group as compared to control. This study thus, reveals that bendiocarb induces genotoxicity and cytotoxicity in the bone marrow cells of Calotes versicolor and the significant level of induction is time dependent.