Present study was performed to determine the changes in the blood picture of the freshwater fish Clarias batrachus naturally infected with intestinal cestodes during February,2013-January,2015 from Latur district. Blood profiling of freshwater fish Clarias batrachus infected with cestode (Lytocestus elongatus) showed significant increase in size of RBC and number of WBC; however significantly lower values of RBC, Hb, PCV, MCV in infected Clarias batrachus as compared with normal one. The haematological parameters of the infected fish Clarias batrachus shows high infection cause macrocytic anaemia, lymphocytosis due to deficiency of related factors. Conspicuous changes in the blood picture of cestode infected freshwater fish Clarias batrachus indicate host-parasite interaction as well as the triggering of defense mechanism in the host against infection.