Water is one of the abundantly available substances in nature and also called and elixir of life. The consequences of water pollution in relation to human health, it is needed for drinking cooking bathing, washing etc. In India hardly 10-12% people get clean drinking water about three million people get affected every year by enteric disease. The rural populations suffer the maximum over 80% population live in rural areas and many of them do not get safe drinking water. Present communication deals physico-chemical assessment of water quality in Satna district of Madhya Pradesh. Ground water samples, collected from 20 different sampling locations of Satna district, revealed that pH of all samples was neutral to slight alkaline. Turbidity of all samples was within permissible limit. Total hardness, total dissolve solid, alkalinity, chloride, nitrate, fluoride, sulphate and phosphate were beyond permissible limit in some samples.