The use of experimental insect Drosophila melanogaster and artificial diet are very important aspect of biological study. However success in raising large broods of such experimental insects under artificial conditions depends mainly on a thorough study of their habits and biology especially of their reaction to different temperatures and relative humidity. In the present study the use of mutant strain (Curled) of Drosophila, a genetically experimental insect was studied in relation to different temperatures at laboratory conditions ranged between 10�C-40�C. The developmental period and longevity was found to be 14, 13, 12, 10, 6, 5 days and 32%, 58%, 74%, 86%, 56%, 42% respectively (P<0.05). The optimum temperature was found to be 25�C for maximum longevity and emergence of adult.