The investigation was carried out to determine the possible bioactive components of Cenchrus ciliaris using Gas chromatography-Mass spectrometry (GC-MS). All the samples were dried firstly at 60�C for 2 days in an oven after that leave it on room temperature. They were then macerated to powder form with a mixer grinder. The powder was stored in air sealed polythene bags at room temperature before extraction. The chemical compositions of the ethyl acetate extract of whole Cenchrus ciliaris plant were investigated using Perkin-Elmer Gas chromatography- Mass spectrometry. While the mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology (NIST) and WILEY-8 library. 103 components of the above said plant were identified. This is the first report of identification of components from the whole plant of Cenchrus ciliaris by GC-MS.