Though, poop therapy was first documented in 4th century China, the Fecal Microbiota Transplantation (FMT) has gained interest recently as a novel treatment option for several incurable gastrointestinal diseases. It seems, now, the time has come to reevaluate the efficiency of FMT as a treatment option which is still in infancy. The present paper discusses the need and urgency of FMT with their treatment modalities of several incurable gastrointestinal human diseases.