The effect of two hormones HCG and DES on the growth and maturation of the Indian river prawn, Macrobrachium malcolmsonii was evaluated. Juveniles of Macrobrachium malcolmsonii (average weight : 15.50�0.40 g for male and 13.90�0.10 g for female) were fed with prepared pelleted feed (25% protein) by incorporating Human Chorionic Gonadotropin (HCG) and Diethylstilbestrol (DES) at 1.0, 1.5 and 2.0 mg l-1 concentrations respectively. After 105 days the prawn fed with HCG incorporated feed at 1.5 mg l-1 showed maximum growth for both sexes (26.50 g for male and 24.25 g for female) and high percentage of maturity (80% for male and 90% for female). The weight in- crement at 1.5 mg l-1 incorporated HCG pelleted feed was found to be higher (10.70 g for male and 10.25 g for female) compared to DES (10.25 g for male and 10.10 g for female). Feed incorporated with HCG and DES at 1.5 mg l-1 can effectively be used in Macrobrachium malcolmsonii culture for promoting growth and early maturation.