In the present study Zingiber officinale (extract) was investigated for hepatoprotective and antioxidant activity against a potent chemical carcinogen dimethyl benz[a]anthracene. Oral cancers were developed in male wistar rats oral cavity by painting with 0.2% DMBA in DMSO thrice a week for 16 weeks. Hundred percent tumor formation (well differentiated squamous cell carcinoma) was noticed in rats treated with DMBA alone. Oral administration of Zingiber officinale extract at a dose of 500 mg/kg to wistar rats treated with DMBA reduced the extent of tumor formation as well as in addition resumed the normal histoarchitecture of liver tissues and showed hepatoprotective activity. Administration of Zingiber officinale (500 mg/kg BW) in the T1 group caused significant reduction of LPO values and significant enhancement in the levels of SOD and Catalase as campared to the DMBA intoxicated group. In conclusion Zingiber officinale (extract) exhibits good hepatoprotective, curative and antioxidant potential against DMBA-induced hepatic dysfunction probably with one possibility of reduction in free radical generation.