Year: 2019, Issue: June

Hepatoprotective and antioxidative potential of Zingiber officinale extract in 7,12 dimethylbenz(A) Anthracene oral carcinogenesis in rodent model.
Author:
A. Shukla and V. K. Sharma
Keyword:
Zingiber officinale, DMBA, Hepatoprotective, DMSO, Squamous cell carcinoma, LPO, SOD, Catalase
In the present study Zingiber officinale (extract) was investigated for hepatoprotective and antioxidant activity against a potent chemical carcinogen dimethyl benz[a]anthracene. Oral cancers were developed in male wistar rats oral cavity by painting with 0.2% DMBA in DMSO thrice a week for 16 weeks. Hundred percent tumor formation (well differentiated squamous cell carcinoma) was noticed in rats treated with DMBA alone. Oral administration of Zingiber officinale extract at a dose of 500 mg/kg to wistar rats treated with DMBA reduced the extent of tumor formation as well as in addition resumed the normal histoarchitecture of liver tissues and showed hepatoprotective activity. Administration of Zingiber officinale (500 mg/kg BW) in the T1 group caused significant reduction of LPO values and significant enhancement in the levels of SOD and Catalase as campared to the DMBA intoxicated group. In conclusion Zingiber officinale (extract) exhibits good hepatoprotective, curative and antioxidant potential against DMBA-induced hepatic dysfunction probably with one possibility of reduction in free radical generation.

Society of Life Sciences

LSB
e - ISSN: 2321-7952
Print ISSN: 0973-5453X
News
Subscriptions
Hard Copy Subscription
Coming Issues
Categories
Animal Science
Agricultural Science
Biotecnology
Microbiology and Virology
Environment
Medical and Forensics
Plant Science
Anatomy and Physiology
Biology
Neuroscience
Ecology
Zoology
1/25
Website Visit Counter
NJLS
e - ISSN: 2321-7960
Print ISSN: 0972-995X