The present study focused on the alteration in clinical manifestations including body weight, food intake, coat pattern, behavioural symptoms and locomotory activities on oral carcinoma wistar rat model. Squamous cell carcinoma has been developed with the chronic exposure of DMBA (0.2%) on rat oral epithelium for the time period of 120th days. Significant alterations in clinical parameters have been reported including decrease in body weight, variation in fur pattern, significant sign of lethargy, dizziness and some reported with convulsions.