This study was undertaken to examine the liver histopathology in the freshwater fish, Tilapia exposed to Neemax (biopesticised). The present study has produced a better perception of the possible disruptions to the aquatic biota exposed to low levels of Neemax biopesticide. Several changes were observed in fish showed respiratory disorder, abnormal swimming behavior rapid opercular movements. Histopathological changes were observed in fish organs would serve useful purpose in evaluating the toxic effect of pesticide. Histopathological changes in liver observed microscopically showed damage in the tissues in correlation with the concentration of Neemax (Biopesticide), while liver of control group exhibited normal architecture.