The main threats to aquatic life are industries which discharges their effluent without treatment into near water bodies. The contaminants in the may pose a risk to early life stage survival and ultimately reduce recruitment into the adult population. To study the response mortality of common carp Catla catla fry against distillery effluent; the fry were exposed to different concentrations of industrial effluent (0.2% to 3.0%) for the period of 96 hrs. The overall survival and mortality of the fry was observed under controlled laboratory conditions. The common carp fry showed high rate of mortality at low concentrations of distillery effluent. The results obtained in this study shows the rate of fry mortality was 20% at concentration 1.1% within 12 hrs exposure. 100% mortality was observed within 12 hr of exposure at 1.3% concentration. 60% mortality was found in 24 hrs at 1.2% concentration. No mortality has been found at the concentration for 0.1 to 0.9% during the period of 96 hrs. No mortality was observed in the control group of larvae.